DOI: Myc-associated zinc-finger protein MAZ is a well-documented oncogene involved in the progression and metastasis of multiple cancer types, even in PCa. However, the clinical significance and biological roles of MAZ in bone metastasis of PCa remain unclear.
Statistical analysis was performed to evaluate the prostate adenocarcinoma correlation between MAZ expression and clinicopathological features and bone metastasis-free survival in PCa patients.
Biological roles of MAZ in bone metastasis of PCa were investigated both in vitro by transwell assay, and in vivo by a mouse model of prostate adenocarcinoma cardiac ventricle inoculation.
The bioinformatics analysis, western blot, pull-down assays, chromatin immunoprecipitation Prostate adenocarcinoma and luciferase reporter assays were applied to demonstrate and examine the relationship between MAZ and its potential downstream signalling pathway.
TaqMan copy number assay was performed to identify the underlying mechanism responsible for MAZ overexpression in PCa tissues. Prostate adenocarcinoma MAZ expression is elevated in PCa tissues with bone metastasis compared with that in PCa tissues without bone metastasis, and is further increased in metastatic bone tissues.
High expression of MAZ positively correlates with poor overall and bone metastasis-free survival in PCa patients. Upregulating MAZ elevates, while silencing MAZ represses the invasion and migration abilities of PCa cells in vitro and bone metastasis ability in vivo.
Department, Sibiu, Romania Adrian Hasegan Lucian Blaga University — Faculty of Medicine, Sibiu, Romania Nicolae Grigore Lucian Blaga University — Faculty of Medicine, Sibiu, Romania Abstract Objective: Ureteral metastasis of prostate cancer is a very rare pathology, that can be confused with an upper urinary tract urothelial carcinoma, with great implications in the surgical management and therapy of the disease. Case: A prostate adenocarcinoma old male patient admitted to the emergency room prostate adenocarcinoma 2 weeks history of left flank pain without low urinary tract symptoms or hematuria. The patient underwent prostate needle biopsy and ureteral biopsy using flexible ureteroscopy, after the Lich-Gregoire ureterovesical reimplantation. In this case, renal colic as the first symptom of a ureteral metastasis secondary to prostate cancer is extremely rare which diagnosed in the patient.
Finally, our results indicate that recurrent gains contribute to MAZ overexpression in a small portion of PCa tissues. MeSH terms.